Publications

  1. Antonopoulos AS, Margaritis M, Verheule S, Recalde A, Sanna F, Herdman L, Psarros C, Nasrallah H, Coutinho P, Akoumianakis I, Brewer AC, Sayeed R, Krasopoulos G, Petrou M, Tarun A, Tousoulis D, Shah AM, Casadei B, Channon KM and Antoniades C. Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-gamma/Adiponectin Signalling. Circ Res. 2016;118:842-55.
  2. Karimi Galougahi K, Antoniades C, Nicholls SJ, Channon KM and Figtree GA. Redox biomarkers in cardiovascular medicine. Eur Heart J. 2015;36:1576-82, 1582a-b.
  3. Antonopoulos AS, Margaritis M, Coutinho P, Shirodaria C, Psarros C, Herdman L, Sanna F, De Silva R, Petrou M, Sayeed R, Krasopoulos G, Lee R, Digby J, Reilly S, Bakogiannis C, Tousoulis D, Kessler B, Casadei B, Channon KM and Antoniades C. Adiponectin as a link between type 2 diabetes and vascular NADPH oxidase activity in the human arterial wall: the regulatory role of perivascular adipose tissue. Diabetes. 2015;64:2207-19.
  4. Antonopoulos AS, Margaritis M, Coutinho P, Digby J, Patel R, Psarros C, Ntusi N, Karamitsos TD, Lee R, De Silva R, Petrou M, Sayeed R, Demosthenous M, Bakogiannis C, Wordsworth PB, Tousoulis D, Neubauer S, Channon KM and Antoniades C. Reciprocal effects of systemic inflammation and brain natriuretic peptide on adiponectin biosynthesis in adipose tissue of patients with ischemic heart disease. Arterioscler Thromb Vasc Biol. 2014;34:2151-9.
  5. Antoniades C and Channon KM. Statins: pleiotropic regulators of cardiovascular redox state. Antioxid Redox Signal. 2014;20:1195-7.
  6. Margaritis M, Channon KM and Antoniades C. Statins as regulators of redox state in the vascular endothelium: beyond lipid lowering. Antioxid Redox Signal. 2014;20:1198-215.
  7. Margaritis M, Antonopoulos AS, Digby J, Lee R, Reilly S, Coutinho P, Shirodaria C, Sayeed R, Petrou M, De Silva R, Jalilzadeh S, Demosthenous M, Bakogiannis C, Tousoulis D, Stefanadis C, Choudhury RP, Casadei B, Channon KM and Antoniades C. Interactions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of endothelial nitric oxide synthase function in human vessels. Circulation. 2013;127:2209-21.
  8. Lee R, Antonopoulos AS, Alexopoulou Z, Margaritis M, Kharbanda RK, Choudhury RP, Antoniades C and Channon KM. Artifactual elevation of plasma sCD40L by residual platelets in patients with coronary artery disease. Int J Cardiol. 2013;168:1648-50.
  9. Lee R, Adlam D, Antoniades C, Digby JE, Kharbanda RK, Choudhury RP and Channon KM. Heparin administration leads to rapid decrease in plasma matrix metalloproteinase-9. Int J Cardiol. 2013;163:212-3.
  10. Lee R, Margaritis M, Channon KM and Antoniades C. Evaluating oxidative stress in human cardiovascular disease: methodological aspects and considerations. Curr Med Chem. 2012;19:2504-20.
  11. Cerrato R, Cunnington C, Crabtree MJ, Antoniades C, Pernow J, Channon KM and Bohm F. Endothelin-1 increases superoxide production in human coronary artery bypass grafts. Life Sci. 2012;91:723-8.
  12. Antonopoulos AS, Margaritis M, Lee R, Channon K and Antoniades C. Statins as anti-inflammatory agents in atherogenesis: molecular mechanisms and lessons from the recent clinical trials. Curr Pharm Des. 2012;18:1519-30.
  13. Margaritis M, Channon KM and Antoniades C. Statins and vein graft failure in coronary bypass surgery. Curr Opin Pharmacol. 2012;12:172-80.
  14. Cunnington C, Van Assche T, Shirodaria C, Kylintireas I, Lindsay AC, Lee JM, Antoniades C, Margaritis M, Lee R, Cerrato R, Crabtree MJ, Francis JM, Sayeed R, Ratnatunga C, Pillai R, Choudhury RP, Neubauer S and Channon KM. Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease. Circulation. 2012;125:1356-66.
  15. Antoniades C, Demosthenous M, Reilly S, Margaritis M, Zhang MH, Antonopoulos A, Marinou K, Nahar K, Jayaram R, Tousoulis D, Bakogiannis C, Sayeed R, Triantafyllou C, Koumallos N, Psarros C, Miliou A, Stefanadis C, Channon KM and Casadei B. Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment. J Am Coll Cardiol. 2012;59:60-70.
  16. Lee R, Channon KM and Antoniades C. Therapeutic strategies targeting endothelial function in humans: clinical implications. Curr Vasc Pharmacol. 2012;10:77-93.
  17. Antoniades C, Cunnington C, Antonopoulos A, Neville M, Margaritis M, Demosthenous M, Bendall J, Hale A, Cerrato R, Tousoulis D, Bakogiannis C, Marinou K, Toutouza M, Vlachopoulos C, Leeson P, Stefanadis C, Karpe F and Channon KM. Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis. Circulation. 2011;124:1860-70.
  18. Lee R, Antoniades C, Adlam D and Channon KM. Treatment of recurrent vein graft “stent-in-stent” re-stenosis guided by optical coherence tomography. Int J Cardiol. 2012;156:e20-1.
  19. Reilly SN, Jayaram R, Nahar K, Antoniades C, Verheule S, Channon KM, Alp NJ, Schotten U and Casadei B. Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins. Circulation. 2011;124:1107-17.
  20. Adlam D, Antoniades C, Lee R, Diesch J, Shirodaria C, Taggart D, Leeson P and Channon KM. OCT characteristics of saphenous vein graft atherosclerosis. JACC Cardiovasc Imaging. 2011;4:807-9.
  21. Antoniades C, Bakogiannis C, Leeson P, Guzik TJ, Zhang MH, Tousoulis D, Antonopoulos AS, Demosthenous M, Marinou K, Hale A, Paschalis A, Psarros C, Triantafyllou C, Bendall J, Casadei B, Stefanadis C and Channon KM. Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling. Circulation. 2011;124:335-45. Antoniades C, Bakogiannis C, Tousoulis D et al. Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity. Circulation 2010;122:S66-73.
  22. Antoniades C, Van-Assche T, Shirodaria C et al. Preoperative sCD40L levels predict risk of atrial fibrillation after off-pump coronary artery bypass graft surgery. Circulation 2009;120:S170-6.
  23. Antoniades C, Shirodaria C, Leeson P et al. MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis. Circulation 2009;119:2507-15.
  24. Antoniades C, Shirodaria C, Leeson P et al. Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis. European heart journal 2009;30:1142-50.
  25. Antoniades C, Antonopoulos AS, Bendall JK, Channon KM. Targeting redox signaling in the vascular wall: from basic science to clinical practice. Curr Pharm Des 2009;15:329-42.
  26. Antoniades C, Mussa S, Shirodaria C et al. Relation of preoperative radial artery flow-mediated dilatation to nitric oxide bioavailability in radial artery grafts used in off-pump coronary artery bypass grafting. The American journal of cardiology 2009;103:216-20.
  27. Antoniades C, Shirodaria C, Van Assche T et al. GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function. Journal of the American College of Cardiology 2008;52:158-65.
  28. Doehring A, Antoniades C, Channon KM, Tegeder I, Lotsch J. Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk. Mutat Res 2008;659:195-201.
  29. Antoniades C, Shirodaria C, Crabtree M et al. Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation. Circulation 2007;116:2851-9.
  30. Antoniades C, Shirodaria C, Stefanadis C, Channon KM. Homocysteine lowering: any use in atherosclerosis? Hellenic J Cardiol 2007;48:249-51.
  31. Lee JM, Shirodaria C, Jackson CE et al. Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus. Diab Vasc Dis Res 2007;4:44-8.
  32. Shirodaria C, Antoniades C, Lee J et al. Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease.Circulation 2007;115:2262-70.
  33. Antoniades C, Shirodaria C, Warrick N et al. 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling. Circulation 2006;114:1193-201.
  34. Adlam D, Antoniades C, Lee R et al. OCT characteristics of saphenous vein graft atherosclerosis. JACC Cardiovascular imaging 2011;4:807-9.
  35. Antoniades C, Mussa S, Shirodaria C et al. Relation of preoperative radial artery flow-mediated dilatation to nitric oxide bioavailability in radial artery grafts used in off-pump coronary artery bypass grafting. The American journal of cardiology 2009;103:216-20.
  36. Antoniades C, Van-Assche T, Shirodaria C et al. Preoperative sCD40L levels predict risk of atrial fibrillation after off-pump coronary artery bypass graft surgery. Circulation 2009;120:S170-6.
  37. Choudhary BP, Antoniades C, Brading AF, Galione A, Channon K, Taggart DP. Diabetes mellitus as a predictor for radial artery vasoreactivity in patients undergoing coronary artery bypass grafting. Journal of the American College of Cardiology 2007;50:1047-53.