REDOxHEART

Welcome to the REDOxHEART webpage!

The Role of Adipose-Tissue Derived wnt-ligands in the Regulation of Myocardial Redox Signalling

Redox signalling is a critical regulator of myocardial physiology and a rationale target in cardiovascular therapeutics, while obesity seems to trigger myocardial oxidative stress. The wnt signalling pathway is a critical regulator of these functions.

The  main aims of the REDOxHEART project are the following:

  • To characterize the downstream  wnt signalling  the human myocardium
  • To explore the mechanisms by which wnt signalling regulates myocardial redox state in adult heart
  • To explore the contribution of  wnt pathways in myocardial hypertrophy
  •  To define the clinical predictive value of circulating/tissue wnt ligands

 

Funding: This project is funded by the European Commission Horizon 2020 (grant No 656990)

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If you would like more information about the REDOxHEART project please contact Dr. Konstantinos Psarros using the form below: