Welcome to the Ox-HVF website

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The Oxford Heart, Vessels & Fat (OX-HVF) cohort consists of a cluster of clinical studies (namely ART Vascular, Bypass Grafts, AdipoRedOx, ORFAN and IMPACT), which provide synergistic results allowing the deployment of a multi-level strategy to understand the mechanisms of cardiovascular diseases. As each one of the individual studies approaches the issue of cardiovascular disease pathogenesis from a different angle, the OX-HVF cohort provides a unique and powerful platform that includes collectively more than 1500 subjects aiming to exceed 4000 by 2020. The strength of the cohort is the direct access to human tissue (vessels, myocardial and fat biopsies, DNA, plasma and others), in combination with extensive non-invasive cardiovascular phenotyping that includes cardiovascular computed tomography angiography, ultrasound and others. The OX-HVF cohort also collects prospective 10-year clinical outcome data and is linked to the NIHR Bioresource.

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Recent Publications


Oikonomou EK., Marwan M., Desai MY., Mancio J., Alashi A., Hutt Centeno E., Thomas S., Herdman L., Kotanidis CP., Thomas KE., Griffin BP., Flamm SD., Antonopoulos AS., Shirodaria C., Sabharwal N., Deanfield J., Neubauer S., Hopewell JC., Channon KM., Achenbach S., Antoniades C. Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data. Lancet. 2018 Sep 15;392(10151):929-939. 


Antonopoulos AS., Sanna F., Sabharwal N., Thomas S., Oikonomou EK., Herdman L., Margaritis M., Shirodaria C., Kampoli A-M., Akoumianakis I., Petrou M., Sayeed R., Krasopoulos G., Psarros C., Ciccone P., Brophy CM., Digby J., Kelion A., Uberoi R., Anthony S., Alexopoulos N., Tousoulis D., Achenbach S., Neubauer S., Channon KM., Antoniades C. Detecting human coronary inflammation by imaging perivascular fat. Sci Transl Med. 2017 Jul 12;9(398). 


Margaritis M., Sanna F., Lazaros G., Akoumianakis I., Patel S., Antonopoulos AS., Duke C., Herdman L., Psarros C., Oikonomou EK., Shirodaria C., Petrou M., Sayeed R., Krasopoulos G., Lee R., Tousoulis D., Channon KM., Antoniades C. Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress. Eur Heart J. 2017;38(41):3094-3104.


Antonopoulos AS, Margaritis M, Verheule S, Recalde A, Sanna F, Herdman L, Psarros C, Nasrallah H, Coutinho P, Akoumianakis I, Brewer AC, Sayeed R, Krasopoulos G, Petrou M, Tarun A, Tousoulis D, Shah AM, Casadei B, Channon KM and Antoniades C. Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-gamma/Adiponectin Signalling. Circ Res. 2016;118:842-55.


Karimi Galougahi K, Antoniades C, Nicholls SJ, Channon KM and Figtree GA. Redox biomarkers in cardiovascular medicine. Eur Heart J. 2015;36:1576-82, 1582a-b.


Antonopoulos AS, Margaritis M, Coutinho P, Shirodaria C, Psarros C, Herdman L, Sanna F, De Silva R, Petrou M, Sayeed R, Krasopoulos G, Lee R, Digby J, Reilly S, Bakogiannis C, Tousoulis D, Kessler B, Casadei B, Channon KM and Antoniades C. Adiponectin as a link between type 2 diabetes and vascular NADPH oxidase activity in the human arterial wall: the regulatory role of perivascular adipose tissue. Diabetes. 2015;64:2207-19.

 

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