The Oxford Heart, Vessels & Fat (OX-HVF) cohort consists of a cluster of clinical studies (namely ART Vascular, Bypass Grafts, AdipoRedOx, and ORFAN), which provide synergistic results allowing the deployment of a multi-level strategy to understand the mechanisms of cardiovascular diseases. As each one of the individual studies approaches the issue of cardiovascular disease pathogenesis from a different angle, the OX-HVF cohort provides a unique and powerful platform. The strength of the cohort is the direct access to human tissue (vessels, myocardial and fat biopsies, DNA, plasma and others), in combination with extensive non-invasive cardiovascular phenotyping that includes cardiovascular computed tomography angiography, ultrasound and others. The OX-HVF cohort also collects prospective 10-year clinical outcome data and is linked to the NIHR Bioresource.

AdipoRedOx_00000

ORFAN_00000

Bypass Vascular Grafts Study

ART-Vasc Study


Recent Announcements

Announcement 13/06/2020

UK C19-CRC: Using AI to measure increased acute and longer-term cardiovascular risk in Covid-19 patients

We are proud to inform participants that the ORFAN study has been awarded a National Flagship Programme status by the British Heart Foundation/National Institute of Health Research (BHF/NIHR) for the UK C19-CRC project. The project takes advantage of novel artificial intelligence (AI) techniques applied to CT chest scans to accurately measure the level of inflammation in the heart which is suspected to be a cause of severe responses to the virus. If you wish to read further information please visit the official BHF website: https://www.bhf.org.uk/for-professionals/information-for-researchers/national-flagship-projects


Announcement 17/02/2020

We would like to inform participants that a new General Data Protection Regulation (GDPR) privacy notice regarding long-term follow-up through NHS Digital has been approved. It is available in the links below:

AdipoRedOx Study: https://oxhvf.com/adiporedox/gdpr-privacy-notice/
ORFAN Study: https://oxhvf.com/orfan/gdpr-privacy-notice/
Bypass Vascular Study: https://oxhvf.com/bypass-vascular-study/gdpr-privacy-notice/
ART Vascular Study: https://oxhvf.com/art-vascular-study/gdpr-privacy-notice/


Recent Publications


Akoumianakis I, Sanna F, Margaritis M, Badi I, Akawi N, Herdman L, Coutinho P, Fagan H, Antonopoulos AS, Oikonomou EK, Thomas S, Chiu AP, Chuaiphichai S, Kotanidis CP, Christodoulides C, Petrou M, Krasopoulos G, Sayeed R, Lv L, Hale A, Naeimi Kararoudi M, McNeill E, Douglas G, George S, Tousoulis D, Channon KM, Antoniades C. Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases. Sci Transl Med. 2019;11(510).


Oikonomou EK, Williams MC, Kotanidis CP, Desai MY, Marwan M, Antonopoulos AS, Thomas KE, Thomas S, Akoumianakis I, Fan LM, Kesavan S, Herdman L, Alashi A, Centeno EH, Lyasheva M, Griffin BP, Flamm SD, Shirodaria C, Sabharwal N, Kelion A, Dweck MR, Van Beek EJR, Deanfield J, Hopewell JC, Neubauer S, Channon KM, Achenbach S, Newby DE, Antoniades C. A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. Eur Heart J. 2019. Sep 3. pii: ehz592.


Oikonomou EK., Marwan M., Desai MY., Mancio J., Alashi A., Hutt Centeno E., Thomas S., Herdman L., Kotanidis CP., Thomas KE., Griffin BP., Flamm SD., Antonopoulos AS., Shirodaria C., Sabharwal N., Deanfield J., Neubauer S., Hopewell JC., Channon KM., Achenbach S., Antoniades C. Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data. Lancet. 2018 Sep 15;392(10151):929-939. 


Antonopoulos AS., Sanna F., Sabharwal N., Thomas S., Oikonomou EK., Herdman L., Margaritis M., Shirodaria C., Kampoli A-M., Akoumianakis I., Petrou M., Sayeed R., Krasopoulos G., Psarros C., Ciccone P., Brophy CM., Digby J., Kelion A., Uberoi R., Anthony S., Alexopoulos N., Tousoulis D., Achenbach S., Neubauer S., Channon KM., Antoniades C. Detecting human coronary inflammation by imaging perivascular fat. Sci Transl Med. 2017 Jul 12;9(398). 


Margaritis M., Sanna F., Lazaros G., Akoumianakis I., Patel S., Antonopoulos AS., Duke C., Herdman L., Psarros C., Oikonomou EK., Shirodaria C., Petrou M., Sayeed R., Krasopoulos G., Lee R., Tousoulis D., Channon KM., Antoniades C. Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress. Eur Heart J. 2017;38(41):3094-3104.


Antonopoulos AS, Margaritis M, Verheule S, Recalde A, Sanna F, Herdman L, Psarros C, Nasrallah H, Coutinho P, Akoumianakis I, Brewer AC, Sayeed R, Krasopoulos G, Petrou M, Tarun A, Tousoulis D, Shah AM, Casadei B, Channon KM and Antoniades C. Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-gamma/Adiponectin Signalling. Circ Res. 2016;118:842-55.


Karimi Galougahi K, Antoniades C, Nicholls SJ, Channon KM and Figtree GA. Redox biomarkers in cardiovascular medicine. Eur Heart J. 2015;36:1576-82, 1582a-b.


Antonopoulos AS, Margaritis M, Coutinho P, Shirodaria C, Psarros C, Herdman L, Sanna F, De Silva R, Petrou M, Sayeed R, Krasopoulos G, Lee R, Digby J, Reilly S, Bakogiannis C, Tousoulis D, Kessler B, Casadei B, Channon KM and Antoniades C. Adiponectin as a link between type 2 diabetes and vascular NADPH oxidase activity in the human arterial wall: the regulatory role of perivascular adipose tissue. Diabetes. 2015;64:2207-19.

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